This is a simple way to clear ALL monsters that are on the floor you are currently on. You merely need to save your game once inside the floor you wish cleared, then proceed to shut your DS off. Turn it back on and load your save game, and voila! All of the monsters on that floor have been defeated and you can continue to mine without any pests. Of course on the next floor you proceed to there will be another new set of monsters, but you may repeat the process if you want.
When you first reach any floor of the Mine, if you did not go too far (in falling), save your game immediately. Defeat all the Dark Creatures and save again. Now, smash all rocks and uncover all squares with your hoe to find special items, but DO NOT SAVE.
When you find any special item, reload your game without saving and go directly to the location of the special item and collect it. Now save your game. Do this again and again until all special items on the floor are found.
WARNING: Always save your game on any floor of the mine before you move at all, as you may fall through a hole in the floor and go too far. Do not walk in the mine if your energy level is at zero. If you fall through a hole, you will pass out as soon as you reach the next floor. It's another reason to save your game immediately.