| Trophy | How to unlock |
| Au (Silver) | Achieve a rating of gold or better in all events.
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| Brain Trust (Bronze) | Complete all consume events.
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| Cleanup (Bronze) | Kill 15 characters with a single whipfist attack.
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| Endless Hunger (Silver) | Consume 200 characters to boost your health.
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| Evolutionary step (Bronze) | Use the upgrade menu to acquire an upgrade.
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| Gunning (Bronze) | Destroy 20 helicopters in a single helicopter flight.
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| Half-Truths (Bronze) | Complete a mission without causing a single military alert.
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| Hard To Kill (Gold) | Complete story mode in any difficulty without dying.
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| In Plain Sight (Bronze) | Evade 10 strike teams.
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| In The Web (Bronze) | Consume 50 web targets.
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| Infiltrator (Bronze) | Infiltrate 10 military bases disguised as a commander.
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| It’s Him! (Bronze) | Patsy 5 military personnel.
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| Mankind is your mask (Silver) | Complete 3 missions without causing a single military alert.
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| Misconception (Bronze) | Destroy 25 infected water towers before they hatch.
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| Nice Guy (Silver) | Complete the game while consuming 10 civilians or fewer.
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| Platinum Trophy | Collect all other trophies.
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| Polymath (Silver) | Collect all hint collectibles scattered across New York City.
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| Pt (Gold) | Achieve a platinum medal in all events.
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| Repossession (Bronze) | Seize 50 vehicles from enemy hands.
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| Return Fire (Bronze) | Catch any object tossed by a hydra; and throw it back.
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| Revenge Revisited (Gold) | Complete story mode on hard difficulty.
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| Self-Deception (Bronze) | Discover what happened to Alex Mercer through the web of intrigue.
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| SME (Bronze) | Gain the ability to drive and fly all vehicles.
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| Speed Bumps (Bronze) | Run over 500 characters in a single tank.
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| Streetwise (Silver) | Collect all landmark collectibles scattered across New York City.
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| Surface-To-Air (Bronze) | Shoot down 50 helicopters while driving armor.
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| The Butcher (Silver) | Kill 50 characters in 5 seconds.
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| The Cleaner (Silver) | Destroy 10 military bases or infected hives in New York City.
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| The First Thread (Bronze) | Unlock the web of intrigue.
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| Threat Elevated (Bronze) | Destroy 25 strike teams.
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| Trail Of Corpses (Silver) | Kill 53,596 infected.
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| Unnatural Selection (Silver) | Acquire all available upgrades.
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| Web Of Knowledge (Gold) | Acquire all nodes of the web of intrigue.
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| Wrecking Yard (Bronze) | Destroy 2,000 Vehicles.
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