| Achievement | How to unlock
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|---|
| All Fired Up (75 points) | Complete all Lavalands missions.
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| Amoebacide Denied (20 points) | Complete Mission 7 on Normal difficulty without using the Poison Probe.
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| Battle Royale (100 points) | Complete the Final mission.
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| Belly of the Beast (10 points) | Complete Mission 11.
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| Belongs in a Museum (15 points) | Complete Mission 5 on Normal difficulty without allowing the Analysis Probe to take damage.
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| Biohazard (10 points) | Complete Mission 4.
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| Blitzkrieg (20 points) | Complete Mission 5 on Normal difficulty without allowing more than 5 cysts to hatch.
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| Boot Up Camp (10 points) | Complete Mission 1.
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| Brutal Legend (60 points) | Complete the campaign on Brutal difficulty.
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| Damage Sponge (30 points) | Complete Mission 12 on Normal difficulty without allowing the Proteus Cyst to take damage.
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| Death From Above (10 points) | Complete Mission 8.
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| Feed and Multiply (10 points) | Complete Mission 1 on Normal difficulty with at least 10 amoebas alive.
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| Fight in the Shade (15 points) | Complete Mission 4 on Normal difficulty without replicating more than 15 times.
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| For Queen and Country (10 points) | Complete Mission 10.
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| Give in to Your Anger (25 points) | Complete Mission 6 on Normal difficulty by killing at least 60% of the enemy amoebas yourself.
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| God Save the Queen (25 points) | Complete Mission 10 on Normal difficulty without allowing the Queen to take damage.
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| If You Can't Beat 'Em (30 points) | Complete Mission 10 on Normal difficulty by purifying at least 50% of the Ursas.
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| Micro Manager (15 points) | Complete Mission 2 on Normal difficulty without losing a single amoeba.
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| Micro Master (30 points) | Complete Mission 11 on Normal difficulty with at least 10 amoebas alive.
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| Mitochondrawhat? (10 points) | Complete Mission 3.
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| Natural Selection (10 points) | Complete Mission 2.
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| Nipped in the Bud (10 points) | Complete Mission 5.
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| No Air Support (25 points) | Complete Mission 8 on Normal difficulty without using meteors to kill Alphas.
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| No One Left Behind (20 points) | Complete Mission 7 on Normal difficulty without losing any units to the Chaos Amoeba.
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| No Probe, No Problem (15 points) | Complete Mission 3 on Normal difficulty without using the Cryo Probe.
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| Patience Is a Virtue (25 points) | Complete Mission 6 on Normal difficulty without losing a single amoeba.
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| Primordial Supremacy (40 points) | Complete Mission 12 on Normal difficulty without deploying a single probe.
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| Return to Normalcy (20 points) | Complete the campaign on Normal difficulty.
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| Rumble in the Reef (10 points) | Complete Mission 6.
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| Save the Forest (40 points) | Complete all Mushroom Forest missions.
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| Shaken, Not Stirred (25 points) | Complete Mission 9 on Normal difficulty by eliminating all enemy amoebas.
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| Stampede! (10 points) | Complete Mission 7.
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| Stretched Thin (15 points) | Complete Mission 3 on Normal difficulty without replicating.
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| Tactical Espionage Alpha (10 points) | Complete Mission 9.
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| The Bear Necessities (40 points) | Complete Mission 11 on Normal difficulty without mutating or purifying any amoebas.
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| The Few, the Proud (10 points) | Complete Mission 8 on Normal difficulty without replicating.
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| The Sweet Sixteen (10 points) | Complete Mission 2 on Normal difficulty without replicating more than 16 times.
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| There Can Be Only One (25 points) | Complete Mission 9 on Normal difficulty without replicating.
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| Under the Sea (60 points) | Complete all Primordial Sea missions.
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| Veteran Scars (40 points) | Complete the campaign on Veteran difficulty.
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| You Shall Not Pass (10 points) | Complete Mission 4 on Normal difficulty without letting an amoeba escape.
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