Killing enemies without touching the ground builds combo. When ever you can aim for big combos since landing a big enough one will reward you with stat upgrades.
Don’t avoid weapons because you don’t like a particular one. They either increase your charge or heal your HP, so skipping them means you’re losing out on those stat gains.
Look for the buffs that give you extra fire-power, like rocket boots or explosive corpses.
Always try and get into the bubbles. There's often health pick-ups in there. Not just hearts but 100 gems, battery and ammo for your Gunboots as well.
Remember to reload frequently. This happens automatically when your Gunboots hit the ground.
If you get four extra HP when you're on full health you'll get another chunk of life.
You can kill turtles, bats and jellies by landing on top of them, if you need to save ammunition. But it has no effect on snails or red orbs.
Gems can be found by killing enemies and destroying objects. Collect them to buy items from the shopkeeper and unlock new styles.