Satisfying the following requirements will unlock additional characters and costumes in Raid Mode.
| Unlockable | How to unlock
|
|---|
| Chris Redfield (Sailor) | Inflict 100,000 damage in a single shot in Raid Mode.
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| Chris Redfield (Wetsuit) | Reach Level 30 in Raid Mode.
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| Clive R. O'Brian | Reach Level 20 in Raid Mode.
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| HUNK | Obtain an S rank on every Raid Mode stage on "Abyss" difficulty.
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| Jack Norman | Clear every Raid Mode stage on "Abyss" difficulty.
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| Jessica Sherawat (Terragrigia) | Reach Level 40 in Raid Mode.
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| Jessica Sherawat (Wetsuit) | Clear every Raid Mode stage on "Trench" difficulty.
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| Jessica Sherwat (Snow) | Clear every Raid Mode stage on "Chasm" difficulty.
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| Jill Valentine (Beach) | Obtain a super-rare weapon.
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| Jill Valentine (Pirate) | Complete the "Ghost Ship" bonus stage.
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| Keith Lumley (Casual) | Obtain an S rank on every Raid Mode stage on "Chasm" difficulty.
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| Keith Lumley (Ninja) | Reach Level 50 in Raid Mode.
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| Keith Lumley (Snow) | Clear Episodes 4-6 in Campaign Mode.
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| Morgan Lansdale | Obtain an S rank on every Raid Mode stage on "Trench" difficulty.
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| Parker Luciani (Beach) | Earn 10 total bonuses in Raid Mode.
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| Parker Luciani (Terragrigia) | Defeat 10,000 enemies in Raid Mode.
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| Quint Cetcham (Casual) | Obtain every super-rare weapon.
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| Quint Cetcham (Snow) | Reach Level 5 in Raid Mode.
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| Rachael Foley | Acquire the "Trinity" bonus for the first time.
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| Raymond Vester | Reach Level 10 in Raid Mode.
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