| Achievement | How to unlock |
| Absolute Threshold (25 points) | Achieve the Gold weapon upgrade rank on the Insanity difficulty.
|
| Astraphobia (25 points) | Complete one level in Story mode while only using Shock Therapy.
|
| Aversion Therapy (15 points) | Complete a level on any difficulty without dying.
|
| Bomber (5 points) | Kill 100 Enemies while using the Dream Cleaner.
|
| Breaker (5 points) | Kill 100 Enemies while using the Hailstorm.
|
| Conjurer (5 points) | Kill 100 Enemies while using the Dragon's Grasp.
|
| Delusions of Grandeur (25 points) | Finish a Deathmatch game with the highest score (with at least 3 other players involved).
|
| Draconist (15 points) | Kill 400 Enemies while using the Dragon's Grasp.
|
| Dreamkiller (20 points) | Defeat a Dreamkiller without taking any damage.
|
| Focused Mind (10 points) | Defeat a Doorkeeper without taking any damage.
|
| Free Association (15 points) | Kill 3 or more opponents at the same time in a Multiplayer game.
|
| Freezer (15 points) | Kill 400 Enemies while using the Hailstorm.
|
| Gunner (5 points) | Kill 100 Enemies while using the Minigun.
|
| Heavy Operator (15 points) | Kill 400 Enemies while using the Minigun.
|
| Heliophobia (25 points) | Complete one level in Story mode while only using the Sunbeam.
|
| Hoplophobia (25 points) | Complete one level in Story mode while only using the Minigun.
|
| Immortal (75 points) | Complete every level on any difficulty without dying.
|
| Instinctual Action (25 points) | Enter Berserker Rage during a Multiplayer game.
|
| Latent Abilities (25 points) | Complete every level on any difficulty without dying in the Subconscious.
|
| Lighter (5 points) | Kill 100 Enemies while using the Sunbeam.
|
| Ligyrophobia (25 points) | Complete one level in Story mode while only using the Dream Cleaner.
|
| Lucid Guardian (45 points) | Complete Story mode on the Insanity difficulty.
|
| Manic Episode (15 points) | Enter Berserker Rage at least once in each level of the game in Story mode.
|
| Master (20 points) | Complete Chapter 4 on any difficulty.
|
| Mastermind (25 points) | Conquer 50 brains in Conquest mode.
|
| Mind Guard (25 points) | Return your team's flag at least 5 times in one CTF match.
|
| OCD (10 points) | Use every weapon at least once in any level of the game in Story mode.
|
| Operative (20 points) | Complete Chapter 2 on any difficulty.
|
| Opiophobia (25 points) | Complete one level without receiving any Health pickups.
|
| Pagophobia (25 points) | Complete one level in Story mode while only using the Hailstorm.
|
| Paladin (15 points) | Kill 400 Enemies while using the Sunbeam.
|
| Poor Sleeper (15 points) | Complete Story mode on the Bad Dream difficulty.
|
| Practitioner (20 points) | Complete Chapter 1 on any difficulty.
|
| Prescription (30 points) | Kill 100 opponents in any Multiplayer game mode.
|
| Psycho Logical (25 points) | Complete a Single Player game in Time Trial mode.
|
| Psychoanalysis (15 points) | Kill 25 opponents in any Multiplayer game mode.
|
| Rhabdophobia (25 points) | Complete one level in Story mode while only using the Dragon's Grasp.
|
| Shocker (5 points) | Kill 100 Enemies while using Shock Therapy.
|
| Simple Jack (25 points) | Complete a Single Player game in Single Weapon mode.
|
| Somnambulist (25 points) | Complete Story mode on the Nightmare difficulty.
|
| Specialist (20 points) | Complete Chapter 3 on any difficulty.
|
| Stormer (15 points) | Kill 400 Enemies while using Shock Therapy.
|
| Technician (15 points) | Kill 400 Enemies while using the Dream Cleaner.
|
| Treatment (50 points) | Kill 300 opponents in any Multiplayer game mode.
|
| Untouchable (30 points) | Kill 10 opponents in a row without dying in a Multiplayer game.
|
| Wisdom (15 points) | Find and enter in all of the Secret areas in any one level of the game.
|
| Xenophobia (15 points) | Kill 10 or more enemies at the same time with any weapon.
|
