| Unlockable | How to unlock |
| 100 Hit Combo - Ownership (25 points) | Execute 100 Hit Combo "Ownership".
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| 250 Hit Combo - Neighborly (50 points) | Execute 250 Hit Combo "Neighborly".
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| 50 Hit Combo - Spider Silk (10 points) | Execute 50 Hit Combo "Spider Silk".
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| Air Combo Skill (15 points) | Defeat 50 Enemies using only Air Combos.
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| Bowling Ball (5 points) | Web Swing-Kick 5 Enemies in a single pass.
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| Complete Story, Act One (50 points) | Complete Act One.
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| Complete Story, Act Two (50 points) | Complete Act Two.
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| Complete Web of Shadows (75 points) | Complete Game.
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| Defeat 100 Enemies (20 points) | Defeat 100 Enemies.
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| Defeat 500 Enemies (35 points) | Defeat 500 Enemies.
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| Encountered (5 points) | Parry then Counter Attack one enemy.
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| Eviction (5 points) | Pull Tech Mech Pilot from his seat.
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| Excessive Spider-Man (15 points) | Complete Half of All Optional Goals.
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| First One Hundred (15 points) | Find 100 Collectibles.
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| Great Power (10 points) | Thwart 25 City Crimes.
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| Great Responsibility (25 points) | Thwart 100 City Crimes.
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| Ground Combo Skill (15 points) | Defeat 50 Enemies using only Ground Combos.
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| Heroic Accumulation (25 points) | Find Half of all Collectibles.
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| Max Out Spider-Man (75 points) | Max Out Spider-Man.
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| No Sweat (50 points) | Defeat 1000 Enemies.
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| Obsessive Spider-Man (25 points) | Complete 60 Bonus Goals.
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| Over the Counter (10 points) | Parry then Counter Attack 100 enemies.
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| Overkill (20 points) | Perform all three types of attacks (Ground, Air, Wall) on a single enemy 10 times.
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| The Bigger They Come... (5 points) | Defeat First Tech Mech.
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| Trampoline (25 points) | Web-Strike Bounce 20 Enemies in succession.
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| Ultimate Spider-Man (50 points) | Purchase all Upgrades.
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| Wall Combo Skill (15 points) | Defeat 50 Enemies using only Wall Combos.
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