| Achievement | How to unlock |
| Alien Maggots are Gonna Pay (10 points) | Finish the "Hollywood Holocaust" level in under 3 minutes.
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| Come Get Some (25 points) | Complete "Shrapnel City" on any difficulty or in co-op.
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| Duke's Mighty Foot (10 points) | Step on 40 enemies after using the Shrinker on them.
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| Game Over (25 points) | Complete "The Birth" on any difficulty or in co-op.
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| Gonna Rip Em' a New One (10 points) | Get 100 total kills in ranked Dukematch games (Online).
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| Hail to the King, Baby (25 points) | Earn respect and get 500 total kills in ranked Dukematch games (Online).
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| Let's Rock (25 points) | Complete "Lunar Apocalypse" on any difficulty or in co-op.
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| Looks Like Cleanup on Aisle 4 (10 points) | Step in a pile of excrement.
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| Oomph, Uugh, Where is it? (10 points) | Find 70 secret areas.
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| Piece of Cake (25 points) | Complete "L.A. Meltdown" on any difficulty or in co-op.
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| See You in Hell (15 points) | Get 250 total kills in ranked Dukematch games (Online).
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| Shake It Baby (10 points) | Tip an exotic dancer.
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