Defeating Flugs:

In the later levels of the game you will encounter new enemies called Flugs. These enemies will be small at first, but they will attack and control anything alive. Use a shotgun on these baby Flug as they tend to group in large numbers. By using the shotgun it will send a storm of bullets and kill most of them that are around. Use a shotgun on the possessed Flug, and it will kill most of them in one shot. This is made easier by the fact that most of them carry shotguns.