Complete the following achievements to unlock Xbox Live Gamerscore points.
| Achievement | How to unlock |
| Agency Athlete (20 points) | Run and jump your way to a 4-star Agility rating.
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| Agency Brawler (20 points) | Punch, jab, kick, and throw your way to a 4-star Strength rating.
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| Agency Explosives Expert (20 points) | Bomb your way to a 4-star Explosives rating.
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| Agency Marksman (20 points) | Hit your target every time to achieve a 4-star Firearms rating.
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| Agency Wheelman (20 points) | Accelerate and slide your way to a 4-star Driving rating.
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| Airtime Assassin (10 points) | Shoot and kill 5 gang members in a single jump (while airborne).
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| Bare-Knuckle Brawler (15 points) | Kill 150 gang members with your bare hands (or thrown objects).
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| Base Jumper (10 points) | Jump from the top of the Agency Tower and land in the water below.
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| Body Armor (10 points) | Use the Harpoon gun to attach 5 gang member corpses to a single vehicle.
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| Body Juggler (20 points) | Use explosives to keep a body up in the air for 10 seconds.
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| Car Juggler (20 points) | Use explosives to keep a car up in the air for seven seconds.
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| Chain Banger (10 points) | Blow up 100 explosive objects in 60 seconds.
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| Confiscator (40 points) | Impound all flagged vehicles and store them in the Agency Garage.
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| Double Trouble (10 points) | Double your fun - complete your first mission in Co-op mode.
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| Driving High (10 points) | Achieve a height of 115 feet or more in a vehicle.
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| Firing Squad (15 points) | Fire away - shoot and kill 500 gang members using firearms.
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| First Blood (10 points) | Eliminate the first of 21 gang bosses.
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| Flippin' Crazy (20 points) | Execute 3 flips of any type in a single jump in any vehicle.
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| Free Runner (50 points) | Collect 500 Agility Orbs.
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| Front Flipper (20 points) | Execute two forward flips in a single jump in a moving vehicle.
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| Global Impact (15 points) | Kill 15 gang members using the Observatory Globe.
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| Hazardous Hangtime (10 points) | Execute a 6-second jump in a vehicle.
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| High Flyer (10 points) | Make your way to the top of the Agency Tower.
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| It's Good To Be Connected (30 points) | Unlock all Supply Points.
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| Los Muertos Cleanser (20 points) | Murder Los Muertos - Kill all Los Muertos gang members.
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| Los Muertos Intel Master (10 points) | Locate all Los Muertos dossier targets.
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| Mad Bomber (15 points) | Show your explosive personality - kill 500 gang members using explosives.
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| Master Agent (40 points) | Earn 4-star ratings in all five skill areas and then max out your Skills Status meters.
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| Orb Hunter (50 points) | Collect 300 Hidden Orbs.
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| Over Our Heads (30 points) | Successfully complete all 12 Rooftop Races.
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| Pack Rat (10 points) | Complete any Stockpile mini-game in Co-op mode in fewer than 2 minutes and 30 seconds.
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| Psych Out (100 points) | Complete all Time Trial missions at the Psychotic difficulty level.
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| Rampage (20 points) | Wreak havoc in 60-second increments.
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| Repo Man (10 points) | Commandeer 100 gang-controlled vehicles.
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| Ring Leader (20 points) | Drive through all of the unique Stunt Markers.
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| Road Warrior (30 points) | Successfully complete all 14 Road Races.
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| Roadkill King (15 points) | Mow down and massacre 175 gang members while driving.
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| Shot-putter (10 points) | Throw any object (other than a grenade) 205 feet or more.
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| Shai-Gen Intel Master (10 points) | Locate all Shai-Gen dossier targets.
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| Shai-Gen Cleanser (50 points) | Assassinate Shai-Gen - Kill all Shai-Gen gang members.
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| Street Racer (20 points) | Win every Street Race using any vehicle(s).
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| Street Racer Elite (150 points) | Win every Street Race using all available vehicles.
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| Stunt Driver (20 points) | Successfully execute five car stunts - front & back flips, barrel rolls, a long jump.
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| Tag Teamer (40 points) | Partner up and complete every mission in Co-op mode.
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| Take Me To Your Supply Point (10 points) | Unlock your first Supply Point.
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| The Trifecta (50 points) | Wipe the city clean by taking out all members of all three gangs.
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| Timed Stunt Driver (20 points) | Execute six car stunts in 60 seconds.
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| Untouchable Agent (15 points) | Kill 200 gang members without dying yourself.
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| Volk Cleanser (40 points) | Eviscerate the Volk - Take out all Volk gang members.
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| Volk Intel Master (10 points) | Locate all Volk dossier targets.
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